of course you can still do a regular 2-way, but in that case you must look for woofers that are known to have good sounding midrange rather than ones that have the most powerful bass.
generally if a driver is suitable for 2-way use the prosound manufacturer will indicate this somewhere in the PDF under “applications” …
if the driver has “subwoofer” in the name it probably isn’t really meant for 2-way use.